Unexplained Infertility


Dr. Suman

Sep 21, 2021

Are you confused by the term “Unexplained Infertility”? Do you want to locate the exact meaning of this word and cure it? What is the reason due to which a person suffers from unexplained infertility? If these are some of the questions popping up in your head, no worries!! In this article, I will discuss in brief unexplained infertility and what is the proper treatment to cure it.

Before going in-depth about unexplained infertility, let me tell you what infertility is? Infertility is not a disease but an issue that is faced by more than 80% population. It is contributed by both male and female factors when the female is unable to get pregnant after having sex with their partner for a longer period. Infertility depends upon certain factors and conditions due to which males and females face this problem.

Now, let us talk about unexplained infertility. It is generally a broader term which states infertility with no cause. In such circumstances, the infertility specialist needs to examine the stimulation of ovaries, semen analysis, quality of sperm, presence of low sperm count, etc. They need to work on various segments since the cause of infertility remains unknown.

There are two types of unexplained infertility: primary and secondary unexplained infertility. Primary unexplained infertility is infertility in which couples never have a child. Secondary unexplained infertility is infertility in which couples do have a child but when women are trying to conceive again for more than a year. 

The infertility specialist keeps a check on hormone levels, stimulation of ovaries, a pelvic scan to check whether the womb of women is healthy or not and fallopian tubes for any kind of blockage. However, if these things come clear, then it is termed secondary unexplained infertility.

What are the unexplained infertility reasons?

It doesn’t mean that you cannot get pregnant. It is just that the doctor has found no apparent reasons why you are unable to get pregnant. There are numerous reasons for unexplained infertility. Some of them are listed below:

  • Abnormalities of Fallopian Tubes: In the normal reproduction process, the fimbria picks up the eggs from ovulation during the process of fertilization. However, the issues in the eggs-picking process or blockage in fallopian tubes cause infertility.
  • Emotional Disturbances: Dealing with psychological problems can also be the reason for infertility.
  • Problem with sperms: Low sperm count or when male inefficient to produce healthy sperm, in such case, sperms don’t penetrate into eggs.
  • Endometriosis Issues: Defects in the wall of a woman uterine, known as the endometrium wall, which prevents the embryo’s implantation in it.
  • Abnormal eggs: The abnormal structure of eggs or egg irregularities enable women to get pregnant.

Are there any unexplained infertility symptoms?

Yes, there are certain symptoms that accompany unexplained infertility. In this section of my article, I will detail out the symptoms listed below:

  • No defects in male infertility.
  • Not able to find out the hormonal cause of infertility.
  • Inefficient to diagnose the failure of the reproductive tract.
  • Unable to get pregnant despite having unprotected sex with a partner.

What are the unexplained infertility treatments?

Couples who are trying to get pregnant should understand that unexplained infertility is not an end map for them. However, the reason remains unknown to them, but it doesn’t mean you can’t eliminate the problem completely and get pregnant again.

 The following treatment Infertility Specialist conducts to rectify the problems of unexplained infertility, 

IUI and IVF treatment

The simplest and easiest Assisted Reproductive techniques to cure infertility problems are IUI and IVF. Intrauterine Insemination is the treatment in which sperms are directly placed in the uterus of the woman. 

The doctor in this treatment cycle places sperm near the fallopian tubes so that it can meet eggs released during the process of ovulation. In-Vitro fertilization is the advanced treatment of IUI in which eggs are combined with the sperms during the fertilization process.

Combination of IUI with Clomid Medication

The doctors use the treatment to treat the infertility issues of males and females. Clomid, also known as Clomiphene citrate, is the medication that goes directly into the brain and pituitary gland to produce a follicle. This treatment is quite useful for those women who have an irregular menstrual cycle.

Clomid helps to block the oestrogen and allows the pituitary gland in the brain to release hormones necessary for stimulation of ovaries in producing eggs. However, Clomid is useful for those women who are below the age of 35 and can enhance their chances of pregnancy. The pregnancy rates through this cycle revolve around 5%-10%.

IUI with Injected Gonadotropins

 Another aggressive form of treatment to treat the issues of unexplained infertility is Gonadotropins infused with IUI. Hormones that are released by the pituitary gland to stimulate the reproductive organs in our body is known as Gonadotropins.

Injecting Gonadotropins into the female body helps them stimulate the ovaries. It is usually done on the second and third day of the cycle to determine the level of blood estrogen level and progress of the vagina through ultrasound. The success rate through this cycle is about 20%-25%, with the possibility of a multiple pregnancy rate of approximately 20%.

Stimulation of Ovaries

During your normal reproduction process, every month, eggs reach to its maturity. Ovarian stimulation helps a maximum number of eggs to reach their maturity level. This process expands your chances of pregnancy. This process is conducted by injecting medicines for the period of 8 to 14 days in the female body to stimulate their ovaries and to produce more eggs.

Is it possible to get natural pregnancy after unexplained infertility?

Yes, it is possible to get pregnant naturally after the diagnosis of such infertility issues. However, you need to take certain medications and supplements which would rectify the issues of ovarian stimulation, secretion of hormones for reproductive organs, and healthy sperm count etc., to ensure the positive chances of conceiving. 

Despite taking advice from your infertility specialist, you can go through your own research to identify the root cause of the problem. However, it is quite difficult to predict the main problem of unexplained infertility. Nevertheless, you can take a closer look at all your blood levels and try taking supplements that might improve your chances of pregnancy.

How to get pregnant with unexplained infertility?

You can get easily pregnant with unexplained fertility because unexplained fertility doesn’t mean there are no chances of getting pregnant. In fact, it means you can get pregnant easily, and there are chances of conceiving without any medical assistance. 

According to the researchers, about 2%-4% of a couple facing the issues of such infertility gets pregnant on their own, and with the help of infertility specialists, they can improve their chances of getting pregnant. However, even if a couple doesn’t get pregnant on its own, various treatments can help them cure their unexplained infertility problems.

Certain fertility medications and supplements such as Clomid’s and Gonadotropin will help the couple to expand their chances of pregnancy. In contrast, IUI, IVF and ovarian stimulation may help you to conceive again and embrace their dream of parenthood. In addition, these treatments will help doctors to know the exact reason for their infertility.

Mention some of the unexplained infertility success stories?

There was a couple named Alexa and James who were trying to have a baby after having unprotected sex for a longer period, but Alexa was unable to conceive. Finally, they consulted the Infertility specialist, who conducted various tests to check the exact reason for their infertility. 

However, apparently, there was no problem detected in their tests, and even the doctor couldn’t understand it. They tried every possible reason to detect the real cause of infertility but couldn’t able to find it and left everything in the hand of gods. After a gap of 2-3 years, Alexa found out she was pregnant. Within 2-3 years, Alexa researched and observed her lifestyle and took certain medications and supplements in it.

Meera and Raj were trying to start their family for almost 3-4 years, and the doctor termed their infertility as “unexplained infertility”. With the help of the doctor, they go through the treatment of IVF with the help of frozen eggs, which ultimately brought back hope and happiness in the couple’s life as Meera got pregnant with twins. However, the kind of emotional strain and stress the couple underwent is difficult to describe in words.


I hope that the article mentioned above must have explained to you better about unexplained infertility. It doesn’t mean that you can’t get pregnant. With the help of an infertility specialist, you can go through the treatments of IUI and IVF to treat your infertility issues.

However, it is very difficult to pinpoint the exact cause of your infertility, but there are certain factors on which unexplained infertility depends upon such as abnormalities of fallopian tubes, abnormal eggs, low sperm count, endometrium problems, etc.


How many couples get diagnosed with unexplained infertility?

It is a common issue which almost 50% of couple faces. However, in unexplained infertility, the reason for infertility is unknown, and doctors try to investigate the problem by conducting various tests.

Can unexplained infertility be cured?

Yes, unexplained infertility can be treated by undergoing several treatments which include, IVF, IUI, Combined IUI with Clomid, IUI with Gonadotropins and Ovarian Stimulation.

When does a couple get a diagnose of unexplained infertility?

Couple visits infertility specialist when the female partner is unable to get pregnant. However, in the diagnosis, when doctors couldn’t investigate the real cause of infertility, then it is said that the couple is diagnosed with unexplained infertility.


Diagnosis and Treatment of Unexplained Infertility (

Unexplained infertility. – Abstract – Europe PMC

Efficacy of treatment for unexplained infertility – ScienceDirect

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